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Pharmacology of Neuromuscular Function


Author: William C. Bowman

Publisher: Butterworth-Heinemann

Publish Date: 21st March 1990

ISBN-13: 9781483193564

Pages: 326

Language: English



Pharmacology of Neuromuscular Function, Second Edition provides information pertinent to drugs that affect membrane potentials of the conduction of action potentials in nerve endings and muscle fibers. This book reviews, in a general way, some of the properties of excitable membranes. Organized into seven chapters, this edition begins with an overview of innervation of striated muscles by somatic efferent nerve fibers. This text then explains the transmission from nerve to muscle, which is mediated by acetylcholine that is synthesized and stored in the axon terminals. Other chapters consider the different steps in the transmission process that occur in the nerve endings, which may be modified by the actions of drugs and toxins. This book discusses as well the primary action of neuromuscular-blocking agents. The final chapter deals with the cytoplasm of a muscle cell or fiber that contains all the usual subcellular organelles, including mitochondria and nuclei. This book is a valuable resource for pharmacologists and anesthetists.

Table of Contents

Preface 1 Striated Muscle Innervation of Striated Muscle Different Types of Muscle Fibers 2 Excitable Membranes Properties of Excitable Membranes Some Membrane-Active Drugs and Toxins 3 Neuromuscular Transmission: Prejunctional Events Introduction Acetylcholine Synthesis Acetylcholine Storage Acetylcholine Release 4 Pharmacological Manipulation of Prejunctional Events Introduction Inhibition of Acetylcholine Synthesis Drugs That Inhibit Vesicular Loading: Vesamicol and Tetraphenylboron Agents and Factors That Modify Acetylcholine Release Nicotinic and Muscarinic Receptors on the Nerve Endings 5 Neuromuscular Transmission: Postjunctional Events Development of the Receptor Concept Postjunctional Acetylcholine Receptors Receptor Function The Endplate Response Summary of Postjunctional Events Receptor Desensitization Acetylcholine Receptors of Denervated Muscle Receptors in Myasthenia Gravis Termination of Acetylcholine Action: Acetylcholinesterase Anticholinesterase Drugs 6 Neuromuscular-Blocking Agents Introduction Non-Depolarizing Acetylcholine Antagonists Curarizing Agents from Natural Sources Mechanism of Action of Tubocurarine Characteristics of Block Produced by Tubocurarine The Basis of Clinical Monitoring Structure-Action Relations Clinically Used Non-Depolarizing Neuromuscular-Blocking Drugs Pharmacokinetics Interactions between Two Non-Depolarizing Neuromuscular-Blocking Drugs ‘The Priming Principle’ Unwanted Effects Unwanted Drug Interactions Involving Neuromuscular-Blocking Agents Reversal Agents Some Potential New Non-Depolarizing Neuromuscular-Blocking Agents Depolarizing Blocking Drugs Variations in Depolarization Block Multiply Innervated Muscle Fibers Succinyldicholine (Suxamethonium) 7 Muscle Contraction Fiber Structure Contraction Drugs Affecting Muscle Contractility References Index