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Pesticide Biotransformation and Disposition


Author: Ernest Hodgson

Publisher: Academic Press

Publish Date: 1st January 2012

ISBN-13: 9780123854827

Pages: 234

Language: English



Biotransformation of Pesticides is an updated, “one-stop” resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health.  This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks.  This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. 

Table of Contents

Dedication from Hayes Handbook of Pesticide Toxicology Third Edition Preface Preface from Hayes Handbook of Pesticide Toxicology Third Edition Contributing Authors Chapter 1. Introduction to Pesticide Biotransformation and Disposition Introduction Relevance of Biotransformation and Disposition Studies Chapter 2. Summary of Methods Used in the Study of Pesticide Biotransformation and Disposition Introduction Analytical Methods for Pesticides and Pesticide Metabolites Uptake, Distribution, and Toxicokinetics Cell Culture, Subcellular Fractions, and Recombinant Enzymes Proteomics Metabolomics Summary Chapter 3. Absorption Introduction Factors that Influence the Transfer and Availability of Chemicals in the Body Absorption Summary and Future Directions Chapter 4. Introduction to Biotransformation (Metabolism) Introduction Reactions Catalyzed in Xenobiotic Metabolism Xenobiotic-Metabolizing Enzymes Phase I Xenobiotic-Metabolizing Enzymes Phase II Xenobiotic-Metabolizing Enzymes Summary and Conclusions Chapter 5. Biotransformation (Metabolism) of Pesticides Introduction External Transformation Biotransformation Metabolism in Humans Toxicity of Metabolites Physiological Factors Affecting Biotransformation Tolerance and Resistance Conclusions Chapter 6. Distribution and Pharmacokinetics Models Introduction Distribution Pharmacokinetics Conclusions Chapter 7. Metabolic Interactions of Pesticides Chemical Factors Affecting Pesticide Metabolism: Introduction Induction Inhibition Biphasic Effects: Inhibition and Induction Activation Hepatotoxicity Conclusions Chapter 8. Pesticide Excretion Introduction Renal Function Biliary Excretion Respiratory Excretion Other Routes of Excretion Cellular Elimination Excretion of Pesticides and Their Metabolites as Biomarkers of Exposure Conclusions Chapter 9. Biotransformation of Individual Pesticides Introduction Selected Pesticides Conclusions Acknowledgments Chapter 10. Summary, Conclusions, and Future Developments Introduction Continuing Need for Pesticide Metabolism Studies New Approaches to Pesticide Metabolism Conclusions Index