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Nerve Agents Poisoning and its Treatment in Schematic Figures and Tables


Author: Jiri Bajgar

Publisher: Elsevier

Publish Date: 15th March 2012

ISBN-13: 9780123914828

Pages: 90

Language: English



Organophosphate compounds, first synthesized in the 1800s, have been used for insecticides, pesticides, and in war and terrorism, such as the 1995 Tokyo subway poisoning. This book provides an in-depth examination of the effects of organophosphates and nerve agents and offers therapeutic and prophylactic countermeasures. Beginning with an overview of milestones in the use of toxic chemicals and chemical warfare agents, the formulae and toxicities of compounds are given, along with tables outlining animal toxicities. Data on various compounds’ inhibitions and subsequent accumulations are also provided. Along with data on organophosphates and nerve agents, possible first aid and medical responses are compared among potential responses in the United States and other countries in the east and west. Using clear schematics and tables, this book provides a detailed account of the most common organophosphates and nerve agents, ideas of how to countermeasure their effects, and offers detailed suggestions for where research needs to proceed in the future. This book will prove useful to students, researchers, and military personnel needing to know more about how to deal with nerve agents.

Table of Contents

Acknowledgments 1. Introduction 2. Chemical Weapons Conclusions 3. Chemical Warfare Agents 4. Organophosphates and Nerve Agents Conclusions 5. Toxicodynamics 5.1 Inhibitory Effectiveness 5.2 Other Effects 5.3 Cholinesterase Determination Conclusions 6. Antidotal Treatment 6.1 Therapeutic and Reactivation Effectiveness 6.2 Development of New Reactivators 6.3 Possibilities of AChE Reactivation 6.4 Available Concentrations of Oximes 6.5 The Way to a Universal Oxime 6.6 Autoinjectors: Approach in Different Countries 6.7 Two- or Three-Chambered Autoinjector Conclusions 7. Prophylaxis 7.1 General Principles 7.2 Prophylactics in Practice Conclusions 8. Conclusions References