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Molecular Genetic Medicine


Author: Theodore Friedmann

Publisher: Academic Press

Publish Date: 28th August 1991

ISBN-13: 9781483262055

Pages: 254

Language: English



Molecular Genetic Medicine, Volume I, provides an overview of the progress in several of the most important areas of modern molecular genetics and medicine. The aim is to present a technical and historical picture of the concept that it is through a thorough understanding of genetics of all kinds of human diseases, even infectious diseases, that effective treatments will finally come. The book opens with a discussion of the origins and development of the Human Genome Project. This is followed by separate chapters on the development of immune-deficient mice as models for human hematopoietic disease; the application of genetic techniques for testing identity and relatedness of persons; and advances in recombinant DNA technology and their applications in drug discovery. The final chapter discusses the impact of molecular biology and molecular evolution on debates about the origin of humans, and about the origins both of the characteristics that they share with other animals and of those that make humans unique.

Table of Contents

Contributors Foreword Preface 1 The Genesis of the Human Genome Project I. Introduction II. Technical and Scientific Background III. Origins of Genome Research Programs IV. Conclusions References 2 Immune-Deficient Mice as Models for Human Hematopoietic Disease I. Introduction II. Hematopoiesis III. Genetic Manipulation of Hematopoietic Stem Cells IV. Engraftment of Human Hematopoietic Cells in Immune-Deficient Mice V. Applications VI. Summary References 3 An Application of DNA Sequencing to a Human Rights Problem I. Introduction: The Historical Context II. The Current State of the Art of Human Identification Using Genetic Techniques III. Sequencing of Mitochondrial DNA (mtDNA) as a Genetic System for Testing Relationships IV. Diversity of the Control Region of Human mtDNA V. Isolation of mtDNA from Various Human Tissues VI. Testing Relationships in Argentina References 4 Molecular Genetics and Drug Discovery I. Introduction II. Therapeutics Produced by Recombinant DNA Technology III. Site-Directed Mutagenesis IV. Genetically Engineered Drug Discovery Tools V. Future Prospects References 5 The Role of Molecular Biology in Human Evolutionary Studies: Current Status and Future Prospects I. Introduction II. The Unique Features of Primate Evolution III. The Primate Family Trees IV. Two Extreme Genetic Models for Human Origins and Evolution V. Human History and the Genetics of Regional Transition VI. Mitochondria and Human Evolution VII. Will It Be Possible to Find a Y-Chromosome Adam? VIII. The Extent of Human Diversity IX. Conclusions References Index