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Mechanobiology in Health and Disease


Author: Stefaan Verbruggen

Publisher: Academic Press

Publish Date: 23rd August 2018

ISBN-13: 9780128129531

Pages: 527

Language: English



Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology.

Table of Contents

1. Techniques for Studying Mechanobiology2. Cell geometric control of nuclear dynamics and its implications3. Mechanobiology Throughout Development4. Cartilage Mechanobiology: how chondrocytes respond to mechanical load5. Advances in Tendon Mechanobiology6. Bone Mechanobiology in Health and Disease7. Vascular Mechanobiology, Immunobiology, and Arterial Growth and Remodeling8. Mechanobiology of the Heart Valve Interstitial Cell: Simulation, Experiment, Discovery9. Platelet receptor-mediated mechanosensing and thrombosis10. Mechanobiology of primary cilia in the vascular and renal systems11. Neuromechanobiology12. Mechanobiology of the eye13. Gastrointestinal mechanosensory function in health and disease14. Mechanobiology of Skin Diseases and Wound Healing15. Mechanobiology of Metastatic Cancer