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Laboratory Animal Medicine


Author: James FoxLynn AndersonGlen OttoKathleen Pritchett-CorningMark Whary

Publisher: Academic Press

Publish Date: 2nd September 2015

ISBN-13: 9780124166134

Pages: 1746

Language: English



Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine’s acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals.The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields.Users will find gold-standard guidance on the study of laboratory animal science, as well as valuable information that applies across all of the biological and biomedical sciences that work with animals.

Table of Contents

List of Reviewers List of Contributors Preface to the Third Edition Chapter 1. Laboratory Animal Medicine: Historical Perspectives I Introduction II Origins of Animal Experimentation III Early Veterinarians in Laboratory Animal Science and Medicine IV The Organizations of Laboratory Animal science V Education and Training in Laboratory Animal Medicine VI ACLAM-Sponsored Texts VII Impact of Laws, Regulations, and Guidelines on Laboratory Animal Medicine VIII Regulation of Animal Research in the United Kingdom and Canada IX Commercial and Academic Breeding of Rodents X Conclusion Acknowledgment References Chapter 2. Laws, Regulations, and Policies Affecting the Use of Laboratory Animals I Introduction II Animal Welfare III Importation and Exportation of Animals and Animal Products IV Hazardous Substances V Nucleic Acid and Nanomaterial Research Guidelines References Chapter 3. Biology and Diseases of Mice I Introduction II Biology III Diseases References Chapter 4. Biology and Diseases of Rats I Introduction II Biology III Diseases Acknowledgment References Chapter 5. Biology and Diseases of Hamsters I Introduction II Syrian Hamster III Chinese Hamster IV Armenian Hamster V European Hamster VI Djungarian Hamster References Chapter 6. Biology and Diseases of Guinea Pigs I Introduction II Biology III Diseases References Chapter 7. Biology and Diseases of Other Rodents I Introduction II Ground Squirrels: Urocitellus, Ictodomys, and Spermophilus III Prairie Dogs: Cynomys IV Pocket Gophers: Geomyidae V Kangaroo Rats: Dipodomys VI Pack Rats: Neotoma VII Grasshopper Mice: Onychomys VIII Deer Mice: Peromyscus IX Rice Rats: Oryzomys X Cane Mice: Zygodontomys XI Cotton Rats: Sigmodon XII White-Tailed Rats: Mystromys XIII Gerbils and Jirds: Meriones XIV Voles: Microtus XV Multimammate Rats/Mice: Mastomys XVI Degus: Octodon XVII Naked Mole Rats: Heterocephalus Glaber References Chapter 8. The Laboratory Woodchuck (Marmota monax) I Introduction II Biology III Diseases IV The Woodchuck as an Experimental Animal Model for HBV Research References Chapter 9. Biology and Diseases of Chinchillas I Introduction II Biology III Diseases References Chapter 10. Biology and Diseases of Rabbits I Introduction II Biology III Diseases References Chapter 11. Microbiological Quality Control for Laboratory Rodents and Lagomorphs I Introduction II Microbiological Quality Specifications III Biosecurity IV Health Monitoring V Outbreak Management and Investigation References Chapter 12. Biology and Diseases of Dogs I Introduction II Biology III Diseases Acknowledgments References Chapter 13. Biology and Diseases of Cats I Introduction II Sources of Cats III Housing IV Breeding Colony Management V Nutrition and Feeding VI Infectious Disease Exclusion and Control Acknowledgments References Chapter 14. Biology and Diseases of Ferrets I Introduction II Biology III Diseases Acknowledgment References Chapter 15. Biology and Diseases of Ruminants (Sheep, Goats, and Cattle) I Introduction II Biology III Diseases References Chapter 16. Biology and Diseases of Swine I Introduction II Biology III Diseases Acronyms Used in Chapter Acknowledgments References Chapter 17. Nonhuman Primates I Introduction II Taxonomy III Biology IV Principles of Colony Management V Medical Management VI Diseases Acknowledgments References Chapter 18. Biology and Diseases of Amphibians I Introduction II Biology III Diseases References Chapter 19. Biology and Diseases of Reptiles I Introduction II Biology III Diseases References Chapter 20. The Biology and Management of the Zebrafish I Introduction II Zebrafish: The Experimental Model in Biomedical Research III Significances of Healthy Management in the Aquatic Animal Facility IV Environmental Factors Important to Zebrafish Health V General Features of Laboratory Zebrafish Facilities VI Nutrition and Feeding of Zebrafish VII Pathogen Control Program VIII Techniques and Anesthesia IX Significant Diseases of Laboratory Zebrafish Acknowledgment References Chapter 21. Biology and Management of Laboratory Fishes I Introduction II Facility Design III Management and Husbandry IV Medical Protocols V Zoonotic Considerations VI Diseases References Chapter 22. Japanese Quail as a Laboratory Animal Model I Introduction II Biology III Laboratory Management and Husbandry IV Breeding and Rearing Quail V Diseases/Welfare Concerns References Chapter 23. Zebra Finches in Biomedical Research I Introduction II History and Taxonomy III Research Uses IV Biology V Laboratory Management and Husbandry VI Diseases/Welfare Concerns References Chapter 24. Preanesthesia, Anesthesia, Analgesia, and Euthanasia I Introduction II Rodents III Rabbits IV Ferrets V Swine VI Small Ruminants VII Nonhuman Primates References Chapter 25. Techniques of Experimentation I Introduction II Identification Methods III Blood Collection and Intravenous Injection IV Vascular Cannulation V Intraperitoneal Injection VI Subcutaneous, Intramuscular, and Intraosseous Injection VII Digestive System VIII Urinary System Techniques IX Respiratory System Techniques X Reproductive System XI Cardiovascular Techniques XII Endocrine System Techniques XIII Orthopedic Procedures for Laboratory Animals XIV Neurosurgical Techniques XV Tumor Transplantation XVI Imaging Techniques XVII Radiotelemetry XVIII Thymectomy Acknowledgments References Chapter 26. Gnotobiotics I Introduction II Terminology III History IV Characteristics of Gnotobiotes V Establishing a Gnotobiotic Facility VI Operation VII Derivation of Germfree Mice VIII. Resources References Chapter 27. Working Safely with Experimental Animals Exposed to Biohazards I Introduction II Risk Assessment III Managing an Animal Biocontainment Program IV Standard Practices V Veterinary Care VI Other Considerations VII Summary References Chapter 28. Selected Zoonoses I Introduction II Viral Diseases III Rickettsial Diseases IV Chlamydial Infections V Bacterial Diseases VI Fungal Diseases VII Protozoal Diseases VIII Helminth Infections IX Arthropod Infestations Acknowledgments References Chapter 29. Xenozoonoses: The Risk of Infection after Xenotransplantation I Introduction II Lessons from Allotransplantation/Historical Perspective III Potential Mechanisms for Cross-Species Infections IV NonViral Agents V Development of SPF Herds VI Potential Benefits of Xenotransplantation and Other Infectious Disease Issues VII Issues after Xenotransplantation References Chapter 30. Occupational Health of Laboratory Animal Workers I Introduction II Occupational Illness and Injury in Laboratory Animal Workers III Occupational Health Approach IV Hazard Identification V Hazard Controls VI Occupational Medicine Services Appendix 30.1 Appendix 30.2 References Chapter 31. Genetic Monitoring of Laboratory Mice and Rats I Introduction II History of Genetic Monitoring III Rodent Strains: Genetic Homogeneity or Genetic Diversity IV SNP Analysis: Testing Strain Background V Allele-Specific Genotyping: Testing Mutant Strains VI Maintaining Strains VII Phenotype Quality Control VIII The Future of GQC IX GQC: Practical Aspects X Conclusions References Chapter 32. Genetically Modified Animals I Introduction II Manipulating Animals for Genetic Modification III Genetic Modification and Technologies IV Colony Management for GM Mice and Rats V Finding Mouse and Rat Resources References Chapter 33. Factors That Can Influence Animal Research I Introduction II Intrinsic Considerations III Extrinsic Considerations References Chapter 34. Animal Models in Biomedical Research I Introduction II What is an Animal Model? III Nature of Research IV History of Animal Use in Biomedical Research References Chapter 35. Research in Laboratory Animal and Comparative Medicine I Introduction II Principles of Experimentation III Role of the Laboratory Animal Specialist in Research IV Research Training V Summary Acknowledgment References Chapter 36. Design and Management of Research Facilities I Introduction II Facility Planning and Design III Environmental Control and Monitoring IV Housing and Equipment V Materials VI Operational Issues VII Conclusions References Chapter 37. Program Management I Introduction and Definitions II Mission and Strategy: Where it All Starts III Managing People IV Managing Money V Managing Operations VI Concluding Remarks Appendix 1 Executive Summary of the 14 Toyota Way Principles (Reprinted with Permission, McGraw-Hill Education Holdings, LLC, Philadelphia, PA) References Chapter 38. Laboratory Animal Behavior I Introduction II Rodents III Rabbits IV Laboratory Dogs and Cats V Nonhuman Primates VI Farm Animals VII Conclusions References Chapter 39. Animal Welfare I Introduction II Animal Welfare as a Key Component in Research, Teaching, and Testing Using Animals III Animal Welfare – A Historical and Philosophical Perspective IV Guidelines and Principles V Strategies to Optimize Animal Welfare VI Examples of Challenging Research and Opportunities for Animal Welfare Optimization VII Science of Animal Welfare VIII Conclusion and Summary References Index