Advances in Clinical Chemistry, Volume 65

Volume 65 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Preface Chapter One: HDL Metabolism and Atheroprotection: Predictive Value of Lipid Transfers Abstract 1 Introduction 2 HDL Composition 3 HDL Subclasses 4 HDL Metabolism and Reverse Cholesterol Transport 5 Other HDL Functions 6 Proatherogenic HDL 7 Cholesterol Ester Transfer Protein 8 Phospholipid Transfer Protein 9 CETP and PLTP in CVD 10 Simultaneous Transfer of Lipids to HDL 11 Conclusion Acknowledgments Chapter Two: Diagnosis of Infection in Critical Care Abstract 1 Background 2 Immunologic Basis of Sepsis 3 New Tools for Bacterial Identification 4 Useful Markers of Infectious Complications According to the Affected Organ and Patient Status 5 Conclusions Chapter Three: Metabolomics in Nephrotoxicity Abstract 1 Introduction 2 Nephrotoxicity or Renal Toxicity 3 Metabolomics in Biomarker Discovery 4 Metabolomics Application in Animal Model-Based Nephrotoxicity 5 Metabolomics in Clinical Nephrotoxicity 6 Conclusion and Future Perspectives Acknowledgments Chapter Four: Metabolic Syndrome in Pediatrics Abstract 1 Introduction 2 Clinical Features of Children with Metabolic Syndrome 3 Metabolic Characteristics of Children and Adolescents with Metabolic Syndrome 4 Prediabetes and Type 2 Diabetes in Youth 5 Nonalcoholic Fatty Liver Disease in Youth 6 Association Between “Lipid partitioning” and Metabolic Syndrome 7 Is There a Healthy Metabolic Phenotype in Obesity? 8 Role of Subcutaneous Fat in the Pathogenesis of Metabolic Syndrome 9 Novel Biomarkers of Metabolic Syndrome 10 Adipocyte Lipid-Droplet Molecules 11 Inflammation Markers Acknowledgments Chapter Five: CSF in Alzheimer’s Disease Abstract 1 Introduction 2 AD—Genetics and Pathophysiology 3 CSF in AD 4 Candidate AD Biomarkers and Markers of Other Pathologies 5 Standardization Efforts 6 Concluding Remarks Acknowledgments Chapter Six: Food Allergy Testing Abstract 1 Food Allergy—A Growing Problem 2 Testing for Food Allergy 3 Conclusions Chapter Seven: Matrix Metalloproteinases in Biologic Samples Abstract 1 Regulation of MMPs 2 Detection of MMPs in Biological Samples, Total Zymogen Versus Enzymatic Activity 3 Confounders of MMP Measurements Index