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Advances in Carbohydrate Chemistry and Biochemistry, Volume 69


Author: Derek Horton

Publisher: Academic Press

Publish Date: 12th December 2013

ISBN-13: 9780124081130

Pages: 320

Language: English



Since its inception in 1945, this serial has provided critical and informative articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

Table of Contents

Obituaries 1. Stephen John Charles Angyal The Andrews Lectures Administration Acknowledgments List of Publications by S. J. Angyal Obituaries 2. John Grant Buchanan List of Publications by J. Grant Buchanan Obituaries 3. Saul Roseman Biosynthesis and Metabolism of Simple Sugars Biosynthesis of Mucin Glycoproteins and Brain Gangliosides Discovery of the Sialyltransferase Catalyzing the In Vitro Biosynthesis of Sialyl-Lactose Biosynthesis of Oligoglycosyl-Glycoproteins Studied at the Johns Hopkins University (1965–1970) Bacterial Phosphotransferase System (PTS) Studied at the Johns Hopkins University (1965–1985) Intercellular Adhesion and the “Fish Theory” from the Johns Hopkins University (1966–1972) Degradation of Chitin and Hexosamine Metabolism in the Sea World (1985–2011) Acknowledgments References Chapter 4. De novo asymmetric synthesis of the pyranoses: From monosaccharides to oligosaccharides Abstract Abbreviations I Introduction II Masamune–Sharpless Approach to the Hexoses III Danishefsky Hetereo-Diels–Alder Approach to Various Pyranoses IV MacMillan Iterative Aldol Approach to Various Pyranoses V Asymmetric Oxidative Biocatalytic Aldol Approach to Various Pyranoses VI Sharpless Dihydroxylation/Enzymatic Aldol Approach 2-Ketoses VII Non-De Novo Asymmetric Approaches to Pyranoses VIII O’Doherty De Novo Approach to Pyranoses Acknowledgments References Chapter 5. Recent advances toward the development of inhibitors to attenuate tumor metastasis via the interruption of lectin–ligand interactions Abstract Abbreviations I Introduction II Roles of Carbohydrates in Tumor Development III Roles of Lectins in Tumor Development IV Developing Anticancer Approaches by Targeting Tumor-Associated Carbohydrate–Lectin Systems V Conclusions References Chapter 6. Bacterial cell-envelope glycoconjugates Abstract Abbreviations I Introduction II Surface-Layer Glycoproteins III Nonclassical Secondary Cell-Envelope Polysaccharides IV Structural Analysis V Cell-Envelope Glycan Biosynthesis VI Glycan Engineering and Applications VII Concluding Remarks References Author Index Subject Index